How to tame a toxic yet life-saving antifungal


Download the Nature Podcast 08 November 2023

In this episode:

00:46 Modifying a fungal drug to make it less hazardous

Amphotericin B is a substance abuse to deal with dangerous fungal infections. While it is reliable versus lots of fungal types, it is likewise very hazardous to kidneys, indicating it is mainly utilized as a drug of last-resort. Today, a group has actually unpicked the system behind the drug’s toxicity, enabling them to customize it and minimize negative effects in human kidney cells. The scientists hope this brand-new variation of the drug might end up being a helpful tool in battling fungal illness.

Research short article: Maji et al.

09:00 Research Highlights

Reconstructing woolly rhino DNA utilizing samples from fossilized hyena dung, and a soft robotic that can carry out surgical treatment inside a whipping heart.

Research Highlight: Woolly-rhino genome emerges from cave hyena’s fossilized poo

Research Highlight: A robot performs heart surgery with a strong but delicate touch

11:26 Phosphorus discovered at the edge of our Galaxy

Phosphorus is an important aspect for life and for world development, however although plentiful in the inner part of the Milky Way, it has actually been undiscovered in the external areas of our Galaxy. Now, scientists have actually determined phosphorus-containing particles substantial ranges from Earth, although precisely how this phosphorus was produced is uncertain. The group suspect that lower-mass stars lag the phosphorus generation, and think that the detection of the aspect might widen the variety of worlds that might be habitable in our Galaxy.

Research short article: Koelemay et al.

18:14 Briefing Chat

What Osiris-REx’s hypersonic pill return might teach scientists about asteroids striking Earth’s environment, and the hereditary research studies that might assist bring back the genomes of Scotland’s threatened ‘Highland tigers’.

Nature News: Asteroid sampler’s hypersonic return thrilled scientists: here’s what they learnt

Nature News: How to keep wildcats wild: ancient DNA offers fresh insights

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